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Journal of Psychopharmacology
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5-HT1A Receptors in major depression

M. Yates

MRC Neurochemical Pathology Unit, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, UK

I.N. Ferrier

MRC Neurochemical Pathology Unit, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, UK

The 5-HT1A receptor has been studied using quantitative tritium film auto radiography in post-mortem frontal cortex of 15 cases suffering from major depression and controls matched for age, sex, post-mortem delay and storage time. 5-HT1A receptor binding in the depressive cohort was not significantly different from control values. No consistent effects of antidepressant medication or mental state at death were seen on the results.

Journal of Psychopharmacology, Vol. 4, No. 2, 69-74 (1990)
DOI: 10.1177/026988119000400204
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