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Failure of clonidine treatment in benzodiazepine withdrawal

Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK

P. Moodley

Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK

M.S. Keshavan

Western Psychiatric Institute and Clinic, 3811 O'Hara Street, Pittsburgh, PA 15213, USA

M.H. Lader

Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK

Six subjects, dependent on benzodiazepines for at least 2 years, were gradually withdrawn, using placebo substitution, while taking clonidine. After withdrawal was complete, subjects were switched to clonidine-placebo. Despite administration of clonidine at doses sufficient to produce a fall in blood pressure, an abstinence syndrome was seen in five of the subjects. In none of these cases was the withdrawal syndrome exacerbated by changing from clonidine to clonidine-placebo. Scores of depression, subjective anxiety, observed anxiety and somatic symptoms did not change throughout the study.

Journal of Psychopharmacology, Vol. 4, No. 1, 42-45 (1990)
DOI: 10.1177/026988119000400107


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