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The differential effects of flumazenil on the psychomotor and amnesic actions of midazolam

Departments of Minimally Invasive Surgery, Royal Northern Hospital, Holloway Road, London N7 and Institute of Urology, Shaftesbury Avenue, London WC2

H. Valerie Curran

Department of Psychiatry, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, U.K.

Forty-four patients given midazolam prior to day-care urological surgery had the benzodiazepine antagonist, flumazenil, or placebo administered postoperatively. Flumazenil reversed the psychomotor impairments induced by midazolam but not its amnesic effects. There was no evidence of resedation for up to 6 h following the use of flumazenil.

Journal of Psychopharmacology, Vol. 4, No. 1, 29-34 (1990)
DOI: 10.1177/026988119000400105


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