This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Przegalinski, E. Articles by Chojnacka-Wójcik, E. Search for Related Content PubMed Articles by Przegalinski, E. Articles by Chojnacka-Wójcik, E. Social Bookmarking                   What's this?

Anticonflict effect of ipsapirone, buspirone and gepirone is not mediated by their common metabolite 1-(2-pyrimidinyl)piperazine

E. Przegaliski

Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31-343 Kraków, Poland

E. Tatarczyska

Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31-343 Kraków, Poland

E. Chojnacka-Wójcik

Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31-343 Kraków, Poland

Pyrimidinylpiperazine anxiolytic drugs-ipsapirone, buspirone and gepirone-dose- dependently increased punished responding in an anticonflict (shock-induced suppression of drinking) paradigm in rats. Similar effect was also produced by their common metabolite 1- (2-pyrimidinyl)piperazine (1-PP). Anticonflict effects of ipsapirone, buspirone and gepirone, administered in maximal doses, were considerably stronger when tested 30 min than 120 min after their administration. Furthermore, anticonflict effects of these drugs, given in subthres hold or medium effective doses, were significantly potentiated by the non-selective drug metabolism inhibitor proadifen. Comparison of these results with literature pharmacokinetic data indicate that the pharmacological effect of ipsapirone, buspirone and gepirone parallels better cerebral concentrations of the parent drugs than 1-PP. Therefore anticonflict activity of the investigated drugs does not seem to be mediated by their common metabolite 1-PP.

Journal of Psychopharmacology, Vol. 3, No. 3, 180-185 (1989)
DOI: 10.1177/026988118900300309


CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				M. Hascoet, M. Bourin, K. G. Todd, and A. Couetoux du Tertre Anti-conflict effect of 5-HT1A agonists in rats: a new model for evaluating anxiolytic-like activity J Psychopharmacol, January 1, 1994; 8(4): 227 - 237. [Abstract] [PDF]

				E. Przegalinski, E. Tatarczynska, and E. Chojnacka-Wojcik Antidepressant-like activity of ipsapirone, buspirone and gepirone in the forced swimming test in rats pretreated with proadifen J Psychopharmacol, January 1, 1990; 4(4): 204 - 209. [Abstract] [PDF]