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Journal of Psychopharmacology
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Effects of paroxetine and maprotiline on mood, perceptual-motor skills and eye movements in healthy volunteers

J.B. Deijen

Department of Psychology, Psychophysiology Division, Free University, Amsterdam, The Netherlands

S.M. Loriaux

Beecham Research Laboratories, Amstelveen, The Netherlands

J.F. Orlebeke

Department of Psychology, Psychophysiology Division, Free University, Amsterdam, The Netherlands

J. de Vries

Department of Psychology, Psychophysiology Division, Free University, Amsterdam, The Netherlands

Sixteen healthy young volunteers (seven females, nine males) received repeated doses of either 30 mg paroxetine, 100 mg maprotiline or placebo in a double-blind crossover study. Each of the three treatments lasted 1 week separated by 2 weeks of no treatment. Treatment order was counterbalanced. Subjects were tested before each treatment period, and after 1 and 7 days of treatment. Measurements were made of mood, perceptual-motor skills, and eye movements including pupil size when subjects were watching a traffic film.

Journal of Psychopharmacology, Vol. 3, No. 3, 149-155 (1989)
DOI: 10.1177/026988118900300305


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