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The behavioural effects of chronic elevation of rat brain GABA by ethanolamine O-sulphate

Department of Medical Pharmacology, Uppsala University, Uppsala, Sweden

S. Lindgren

Department of Medical Pharmacology, Uppsala University, Uppsala, Sweden

B.J. Meyerson

Department of Medical Pharmacology, Uppsala University, Uppsala, Sweden

This study examined the functional effects of long-term elevated brain GABA concentrations. The increase in GABA was achieved by use of the GABA-aminotransferase (GABA-T) inhibitor, ethanolamine O-sulphate (EOS). Forms of exploratory behaviour pre viously demonstrated to be sensitive to GABAergic receptor stimulation were measured over a 4 week period of EOS treatment. The most pronounced behavioural effect was an increased duration of investigating behaviour following 2-21 days of EOS treatment. This effect was accompanied by an accumulation of GABA in the substantia nigra and the corpus striatum. After 28-30 days of EOS treatment the GABA concentration was still significantly elevated, whereas the investigating behaviour was no longer different from controls.

Journal of Psychopharmacology, Vol. 3, No. 3, 135-141 (1989)
DOI: 10.1177/026988118900300303


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