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Increased slow wave sleep with 5-HT2 receptor antagonists: detection by ambulatory EEG recording and automatic sleep stage analysis

MRC Unit of Clinical Pharmacology and University, Department of Psychiatry, Research Unit, Littlemore Hospital, Oxford OX4 4XN, UK

A.L. Sharpley

MRC Unit of Clinical Pharmacology and University, Department of Psychiatry, Research Unit, Littlemore Hospital, Oxford OX4 4XN, UK

P.J. Cowen

MRC Unit of Clinical Pharmacology and University, Department of Psychiatry, Research Unit, Littlemore Hospital, Oxford OX4 4XN, UK

The effect on slow wave sleep (SWS) of 5-HT antagonists with different affinities for 5-HT₁ and 5-HT₂ receptors was investigated using ambulatory EEG monitoring in normal volunteers. The selective 5-HT ₂ antagonists, ritanserin and cypropheptadine, increased SWS while the non-selective 5-HT antagonist metergoline did not. The histamine H ₁-receptor antagonist, mepyramine, was similarly without effect on SWS. These findings suggest that home ambulatory monitoring with automatic sleep stage analysis may be useful in detecting the effect of selective 5-HT ₂ receptor antagonists on SWS.

Journal of Psychopharmacology, Vol. 3, No. 3, 125-129 (1989)
DOI: 10.1177/026988118900300301


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