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Antidepressant treatments, including electroconvulsive shock and the putative antidepressant sibutramine hydrochloride, do not alter [3H]-prazosin binding to rat cortical membranes

Research Department, The Boots Company plc, Nottingham NG2 3AA, UK

I. Phillips

Research Department, The Boots Company plc, Nottingham NG2 3AA, UK

D.J. Heal

Research Department, The Boots Company plc, Nottingham NG2 3AA, UK

W.R. Buckett

Research Department, The Boots Company plc, Nottingham NG2 3AA, UK

Treatment for 1, 3 or 10 days with sibutramine hydrochloride (3 mg/kg), desi pramine (10 mg/kg), amitriptyline (10 mg/kg) or pargyline (10 mg/kg) did not effect the number or affinity of ₁-adrenoceptors as determined by [³H]-prazosin binding to rat cerebral cortical membranes. Similarly, neither single, nor repeated (five times over 10 days) electroconvulsive shocks, given under halothane anaesthesia had any effect on the parameters of [³H]-prazosin binding. These data suggest that the clinical actions of these treatments are unlikely to involve changes in ₁-adrenoceptor function.

Journal of Psychopharmacology, Vol. 3, No. 2, 70-75 (1989)
DOI: 10.1177/026988118900300204


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