This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Johansson, C. Articles by Ahlenius, S. Search for Related Content PubMed Articles by Johansson, C. Articles by Ahlenius, S. Social Bookmarking                         What's this?

Evidence for the involvement of 5-HT1A receptors in the mediation of exploratory locomotor activity in the rat

Department of Neuropharmacology, Astra Research Centre, S-151 85 Södertälje, Sweden

Sven Ahlenius

Department of Neuropharmacology, Astra Research Centre, S-151 85 Södertälje, Sweden

The 5-HT_1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), 0.1 mg/kg^-1 subcutaneously, produced a suppression of horizontal ('locomotion') and vertical ('rearing') activity, in an open field arena. This effect was partially antagonized by treatment with (-)pindolol, 2 mg/kg^-1 subcutaneously. (-)Pindolol by itself produced a small, but statistically significant suppression of locomotor activity. There were no effects on rearing activity by (—)pindolol. In comparison with saline-treated controls, 8-OH-DPAT increased peripheral, relative to total, horizontal activity in the open field arena. (-)Pindolol adminis tration restored this pattern of activity to normal levels in 8-OH-DPAT-treated animals, without altering the relation peripheral to total activity by itself.

Journal of Psychopharmacology, Vol. 3, No. 1, 32-35 (1989)
DOI: 10.1177/026988118900300106


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				K. S. Panickar and N. McNaughton Dose-response analysis of the effects of buspirone on rearing in rats J Psychopharmacol, January 1, 1991; 5(1): 72 - 76. [Abstract] [PDF]