This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Lister, R. G. Search for Related Content PubMed Articles by Lister, R. G. Social Bookmarking                         What's this?

Antagonizing the behavioural effects of drugs: a discussion with specific reference to benzodiazepines and alcohol

Laboratory of Clinical Studies, NIAAA, DICBR, Building 10, Room 3C218, 9000 Rockville Pike, Bethesda, Maryland 20892, USA

It can be extremely difficult to interpret the results of experiments in which a treatment is found to antagonize the behavioural effects of a drug. This article discusses strategies that can be used to help identify the nature of the antagonism and examines what such experiments tell us about the mechanisms underlying the drug's behavioural effects. Examples are taken from research with both benzodiazepines and ethanol. It is suggested that behavioural studies using different strategies to reduce the effects of a drug will further enhance our understanding of the mechanisms mediating the drug's effects. Such studies will include comparisons between the effects of chronic drug exposure (tolerance studies), genetic manipulations, and pharmacological treatments.

Journal of Psychopharmacology, Vol. 3, No. 1, 21-28 (1989)
DOI: 10.1177/026988118900300104


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?