SAGE Journals Online
Advertisement
Sign In to gain access to subscriptions and/or personal tools.

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Advertisement

Sign In to gain access to subscriptions and/or personal tools.
Journal of Psychopharmacology
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
0269881108095082v1
0269881108095082v2
23/8/1001    most recent
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Kuloglu, M.
Right arrow Articles by Yilmaz, E.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kuloglu, M.
Right arrow Articles by Yilmaz, E.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Lamotrigine-induced obsessional symptoms in a patient with bipolar II disorder: a case report

M. Kuloglu

Department of Psychiatry, Ataturk Education and Research Hospital, Ankara, Turkey, kuloglum{at}yahoo.com

A. Caykoylu

Department of Psychiatry, Ataturk Education and Research Hospital, Ankara, Turkey

O. Ekinci

Department of Psychiatry, Ataturk Education and Research Hospital, Ankara, Turkey

E. Yilmaz

Department of Psychiatry, Ataturk Education and Research Hospital, Ankara, Turkey

Lamotrigine is an anticonvulsant that appears to have a mainly antidepressant effect and is indicated for the maintenance treatment of bipolar depression. Literature associated with obsessional symptoms related to lamotrigine treatment is limited. We report the emergence of obsessive symptoms during treatment with lamotrigine in a patient who subsequently experienced significant improvement after dose reduction and stopping of this medication. The obsessive symptoms associated with lamotrigine treatment were observed after the lamotrigine dose was increased to 100 mg/day. The possible mechanisms, including inhibition on the presynaptic release of glutamate and alteration of striatal dopamine uptake, are discussed. It is unclear why lamotrigine induces obsessions in some patients. Controlled studies are necessary to identify the population at risk for obsessionality in bipolar illness following treatment with lamotrigine and to investigate a possible dose—response relationship between obsessive symptoms and lamotrigine.

Key Words: dopamine • glutamate • lamotrigine • obsession

This version was published on November 1, 2009

Journal of Psychopharmacology, Vol. 23, No. 8, 1001-1003 (2009)
DOI: 10.1177/0269881108095082
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?




Advertisement