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Journal of Psychopharmacology
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0269881108091252v1
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research-article

Hyperprolactinemia and possibly related development of prolactinoma during amisulpride treatment; three cases

C Akkaya

Medical Faculty, Psychiatry Department, Uludag University, Bursa, Turkey cakkaya{at}uludag.edu.tr

B Kaya

Medical Faculty, Psychiatry Department, Uludag University, Bursa, Turkey

Z Kotan

Medical Faculty, Psychiatry Department, Uludag University, Bursa, Turkey

A Sarandol

Medical Faculty, Psychiatry Department, Uludag University, Bursa, Turkey

C Ersoy

Medical Faculty, Endocrinology Department, Uludag University, Bursa, Turkey

S Kirli

Medical Faculty, Psychiatry Department, Uludag University, Bursa, Turkey

Abstract

Schizophrenia is a chronic and debilitating psychotic mental disorder that affects about 1% of the world's population. Antipsychotic drugs are the mainstay of treatment in schizophrenia. Hyperprolactinemia, which is a common side effect of typical antipsychotics, is also associated with the use of some of the newer atypical agents. Antipsychotics may enhance prolactinoma growth as manifested by an increase in serum prolactin concentration. Prolactin-secreting pituitary adenomas possibly related with antipsychotics have been described in the literature. To our knowledge, this is the first series of cases showing a possible relation between pituitary adenomas and amisulpride treatment in patients with schizophrenia.

Key Words: amisulpride • hyperprolactinemia • pituitary adenoma

This version was published on August 1, 2009

Journal of Psychopharmacology, Vol. 23, No. 6, 723-726 (2009)
DOI: 10.1177/0269881108091252
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