This Article Full Text (PDF) All Versions of this Article: 0269881108093926v1 23/6/645    most recent References Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Scopus Google Scholar Articles by Zarrindast, M. Articles by Ahmadi, S PubMed PubMed Citation Articles by Zarrindast, M. Articles by Ahmadi, S Pubmed/NCBI databases Compound via MeSH Substance via MeSH Hazardous Substances DB APOMORPHINE LITHIUM CHLORIDE LITHIUM COMPOUNDS Social Bookmarking                         What's this?

Repeated administrations of dopamine receptor agents affect lithium-induced state-dependent learning in mice

Department of Pharmacology, School of Medicine and Iranian National Centre for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran; Institute for Studies in Theoretical Physics and Mathematics, School of Cognitive Sciences, Tehran, Iran; Institute for Cognitive Science Studies, Tehran, Iran zarinmr{at}ams.ac.ir

F Madadi

Department of Basic Sciences, Tehran North Unit, Azad University, Tehran, Iran

S Ahmadi

Department of Biological Science & Biotechnology, Faculty of Science, University of Kurdistan, Sanandaj, Iran

Abstract

The influence of repeated administration of dopamine receptor agents on the effect of lithium on lithium-induced state-dependent learning was examined in mice. Immediate post-training intraperitoneal (i.p.) administrations of lithium (10 and 20 m/kg) decreased the step-down latency of a single-trial inhibitory avoidance task. This was fully or partly reversed by pre-test administration of the same doses of the drug, with maximum response at the dose of 10 mg/kg, suggesting state-dependent learning was induced by lithium. Here, it has also been shown that repeated intracerebroventricular administrations of a mixed D1/D2 dopamine receptors agonist apomorphine (once daily injections of 0.5 µg/mouse for three consecutive days followed by five days of no drug treatment) increased the effect of lower doses of pre-test lithium (1.25, 2.5 and 5 mg/kg, i.p.) on the reinstatement of the step-down latency decreased by post-training lithium (10 mg/kg). On the contrary, not only repeated administrations of the dopamine D1 receptor antagonist SCH 23390 (0.5 and 1 µg/mouse) but also the dopamine D2 receptor antagonist sulpiride (0.3 and 1 µg/mouse) disrupted the state-dependent learning induced by lithium. These results suggest that state-dependent learning induced by lithium may be altered by repeated pretreatment of dopamine receptor agents.

Key Words: apomorphine • lithium • memory • mouse • SCH23390 • sulpiride

This version was published on August 1, 2009

Journal of Psychopharmacology, Vol. 23, No. 6, 645-651 (2009)
DOI: 10.1177/0269881108093926


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?