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Journal of Psychopharmacology
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0269881108089808v1
23/2/216    most recent
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research-article

Recurrent relapses of depression in a patient established on sertraline after taking herbal medicinal mixtures – a herb–drug interaction?

KPRC Prasad

Department of Pharmacology, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka ruwan{at}med.ruh.ac.lk

PGD Tharangani

Department of Pharmacology, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka

CN Samaranayake

Department of Pharmacology, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka

Abstract

We describe a patient with depression who was well controlled with sertraline monotherapy developing two relapses of depression in close temporal relationship with starting ayurvedic herbal mixtures. We discuss the possibility of a pharmacokinetic herb–drug interaction decreasing the therapeutic efficacy of sertraline leading to the relapses of depression. We speculate the herbal plant most likely to be responsible for this interaction is either Terminalia chebula or Commiphora wighteii.

Key Words: Commiphora wighteii • cytochrome P450 • depression • herb–drug interaction • sertraline • Sri Lanka • SSRI • Terminalia chebula

This version was published on March 1, 2009

Journal of Psychopharmacology, Vol. 23, No. 2, 216-219 (2009)
DOI: 10.1177/0269881108089808
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