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Journal of Psychopharmacology
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0269881107083849v1
22/8/923    most recent
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*Schizophrenia
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Olanzapine plasma concentration in a newborn

W. Aichhorn

Department of Psychiatry and Psychotherapy, PMU Salzburg, Austria, w.aichhorn{at}salk.at

K. Yazdi

Department of Psychiatry and Psychotherapy, PMU Salzburg, Austria

K. Kralovec

Department of Psychiatry and Psychotherapy, PMU Salzburg, Austria

H. Steiner

Department of Gynaecology, PMU Salzburg, Austria

S. Whitworth

Department of Psychiatry and Psychotherapy, PMU Salzburg, Austria

C. Stuppaeck

Department of Psychiatry and Psychotherapy, PMU Salzburg, Austria

Little is known about the use of antipsychotics in pregnancy and the corresponding plasma levels in the newborn child. We report on a woman with schizophrenia treated with olanzapine during pregnancy. Plasma levels of olanzapine were assessed both from the mother and from umbilical cord. The plasma level of the newborn (11 ng/mL) was about one third compared to the mother (range 25—34 ng/mL).The development of the fetus, delivery and the development of the child during the first six months were normal.

Key Words: olanzapine • plasma concentration • umbilical cord • newborn • pregnancy

This version was published on November 1, 2008

Journal of Psychopharmacology, Vol. 22, No. 8, 923-924 (2008)
DOI: 10.1177/0269881107083849
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