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Journal of Psychopharmacology
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0269881107082905v1
22/7/812    most recent
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Delusional disorder, somatic type treated with aripiprazole—mirtazapine combination

NP Dimopoulos

Psychiatric Clinic, "Asklepeion" Hospital, Athens, Greece, dmpnikos{at}yahoo.gr

CI Mitsonis

Psychiatric Hospital of Attiki, "Dafni" - Medical School, University of Athens, Athens, Greece

VV Psarra

Psychiatric Hospital of Attiki, "Dafni", Athens, Greece

Delusional disorder, somatic type (DDST) is a rare psychiatric disorder and the treatment is mostly based on observations, due to the lack of well-organized studies. Initially, antipsychotics and especially pimozide were considered to be the pharmacological approach of choice but, subsequently, tryciclic anti—depressants and selective serotonin re—uptake inhibitors (SSRIs) were also suggested to be effective, implicating the serotonergic system in the pathophysiology of the disorder. We present the case of a female with DDST, who responded to aripiprazole—mirtazapine combination, a finding that is in accordance with the initial approach of this disorder as a part of the schizophrenic spectrum, but also supports the hypothesis of serotonin dysfunction in DDST.

Key Words: delusional disorder • somatic type • aripiprazole • mirtazapine

This version was published on September 1, 2008

Journal of Psychopharmacology, Vol. 22, No. 7, 812-814 (2008)
DOI: 10.1177/0269881107082905
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