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Lamotrigine treatment of aggression in female borderline patients, Part II: an 18-month follow-up

P. Leiberich

Inntalklink, Simbach am Inn, Germany

MK Nickel

Clinic for Psychosomatic Medicine and Psychotherapy, Medical University of Graz, Bad Aussee, Austrian University Clinic for Psychiatry 1, PMU, Salzburg, Austria, m.nickel{at}klinik-badaussee.at

K. Tritt

Department of Psychosomatic Medicine, University Clinic, Regensburg, Germany

F Pedrosa Gil

Psychosomatic Outpatient Clinic, University Medicine Clinic, LMU, Munich, Germany

Borderline patients often display pathological aggression. We previously tested lamotrigine, an anti-convulsant, in therapy for aggression in women with borderline personality disorder (BPD) (J Psychopharmacol 2005; 19: 287—291), and found significant changes on most scales of the State-Trait Anger Expression Inventory (STAXI) after eight weeks. To assess the longer-term efficacy of lamotrigine in therapy for aggression in women with BPD, this 18-month follow-up observation was carried out, in which patients (treated with lamotrigine: n = 18; former placebo group: n = 9) were tested every six months. According to the intent-to-treat principle, significant changes on all scales of the STAXI were observed in the lamotrigine-treated subjects. All subjects tolerated lamotrigine relatively well. Lamotrigine appears to be an effective and relatively safe agent in the longer-term treatment of aggression in women with BPD.

Key Words: borderline personality disorder • aggression • lamotrigine

This version was published on September 1, 2008

Journal of Psychopharmacology, Vol. 22, No. 7, 805-808 (2008)
DOI: 10.1177/0269881107084004
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