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8-OH-DPAT inhibits both prandial and waterspray-induced grooming

Department of Psychology, London Metropolitan University, Old Castle Street, London, UK

AMJ Montgomery

Department of Psychology, University of Greenwich, Avery Hill Road, Eltham, London, UK, a.m.j.montgomery{at}gre.ac.uk

The effects of 8-OH-DPAT treatment on rat grooming behaviour, elicited either prandially or in response to spraying with water were investigated. Dose (0.1 mg/kg s.c.) response studies employed momentary time sampling over 30 or 60 min with behaviour being scored in one of 6 or 7 (depending on food availability) mutually exclusive categories (feeding, active, scratching, face-grooming, body grooming, genital-grooming and resting) at 15 s intervals. In non-deprived rats, tested with wet mash available, feeding and activity frequencies were increased, but resting and total grooming were inhibited by 8-OH-DPAT. Face-, body- and genital-grooming occurred at higher levels than scratching, but all categories were reduced with reductions in scratching occurring at a lower dose (0.01 mg/kg). Misting rats with a fine water spray selectively increased body grooming and decreased activity without altering feeding, while 8-OH-DPAT increased feeding and reduced face-, body- and genital-grooming, without affecting already low levels of scratching. In misted rats, tested without food, 8-OH-DPAT reduced face-, body- and genital-grooming and increased resting. These results confirm i) that the water spray technique is a useful method for increasing grooming and ii) that 8-OH-DPAT has a suppressant effect on grooming independent of response competition from enhanced feeding.

Key Words: 8-OH-DPAT • grooming behaviour • microstructural analysis • obsessive-compulsive disorder

This version was published on September 1, 2008

Journal of Psychopharmacology, Vol. 22, No. 7, 746-752 (2008)
DOI: 10.1177/0269881107082903


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