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Journal of Psychopharmacology
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0269881107082126v1
22/5/574    most recent
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What's this?

An unusual case of prolonged tinnitus following low-dose amitriptyline

D. Mendis

Department of ENT Surgery, Queen's Hospital, Burton-on-Trent, UK, dulanimendis{at}yahoo.com

M. Johnston

Department of ENT Surgery, Derby Royal Infirmary NHS Foundation Trust, Derby, UK

We report on a case of unilateral tinnitus after a short course of low-dose amitriptyline for neuralgic foot pain. This has been described in the literature previously at much higher doses and is associated with prolonged administration; we present our case with a review of the current literature in-order to raise awareness of this possible complication of anti-depressant therapy. We also propose a novel hypothesis for the pharmacological basis of amitriptyline-induced tinnitus.

Key Words: amitriptyline • ototoxicity • tinnitus

This version was published on July 1, 2008

Journal of Psychopharmacology, Vol. 22, No. 5, 574-575 (2008)
DOI: 10.1177/0269881107082126
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