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DOI: 10.1177/0269881108091068 Establishing non-inferiority in treatment trials in psychiatry — guidelines from an Expert Consensus MeetingPsychopharmacology Unit, University of Bristol, Bristol, UK, david.j.nutt{at}bristol.ac.uk
Karolinska Institute, Karolinska University Hospital Huddinge, Huddinge, Sweden
La Salpêtrière - Pavillon Clérambault, Boulevard de l'Hôpital, Paris, France
Department of Community Based Medicine, Academic Unit of Primary Health Care, University of Bristol, Bristol, UK
Fachrichtung Psychologie, TU Dresden, Dresden, Germany Comparing the efficacy of different treatments in psychiatry is difficult for many reasons, even when they are investigated in `head-to-head' studies. A consensus meeting was, therefore, held to produce best practice guidelines for such studies. This article presents the conclusions of this consensus and illustrates it using published data in the field of antidepressant treatment of generalized anxiety disorder.
Key Words: clinical trials duloxetine GAD non-inferiority venlafaxine
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