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Establishing non-inferiority in treatment trials in psychiatry — guidelines from an Expert Consensus Meeting

D Nutt

Psychopharmacology Unit, University of Bristol, Bristol, UK, david.j.nutt{at}bristol.ac.uk

C Allgulander

Karolinska Institute, Karolinska University Hospital Huddinge, Huddinge, Sweden

Y Lecrubier

La Salpêtrière - Pavillon Clérambault, Boulevard de l'Hôpital, Paris, France

T Peters

Department of Community Based Medicine, Academic Unit of Primary Health Care, University of Bristol, Bristol, UK

U Wittchen

Fachrichtung Psychologie, TU Dresden, Dresden, Germany

Comparing the efficacy of different treatments in psychiatry is difficult for many reasons, even when they are investigated in `head-to-head' studies. A consensus meeting was, therefore, held to produce best practice guidelines for such studies. This article presents the conclusions of this consensus and illustrates it using published data in the field of antidepressant treatment of generalized anxiety disorder.

Key Words: clinical trials • duloxetine • GAD • non-inferiority • venlafaxine

Journal of Psychopharmacology, Vol. 22, No. 4, 409-416 (2008)
DOI: 10.1177/0269881108091068
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