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Selectively increased trace conditioning under the neurotensin agonist PD 149163 in an aversive procedure in which SR 142948A was without intrinsic effect

Institute of Neuroscience, Schools of Psychology and Biomedical Sciences, University of Nottingham, Nottingham, UK

C Norman

Institute of Neuroscience, Schools of Psychology and Biomedical Sciences, University of Nottingham, UK

GW Bennett

Institute of Neuroscience, School of Biomedical Sciences, University of Nottingham, Nottingham, UK

HJ Cassaday

Institute of Neuroscience, School of Psychology, University of Nottingham, Nottingham, UK, helen.cassaday{at}nottingham.ac.uk

There is evidence to suggest that neurotensin (NT) may enhance cognitive function. The present study, therefore, examined the role of NT in associative learning between a conditioned stimulus (CS) and an unconditioned stimulus (UCS). This was tested in a trace procedure using conditioned suppression of drinking with a noise CS and foot shock UCS. We compared the effects of an NT agonist (PD 149163, 0.25 and 1 mg/kg) with those of an NT antagonist (SR 142948A, 0.01 and 0.1 mg/kg). Conditioning after drug treatment was followed by drug-free tests of associative learning. At 0.25 but not 1 mg/kg, PD 149163 selectively increased conditioning over the trace interval: there was no such increased conditioning in the 0s group. This increased conditioning over the trace is an effect that is reliably produced by dopamine (DA) agonists in the same procedure. However, dissimilar to the effects of DA agonists, conditioning to box context, was reduced under PD 149163. Doses of SR 142948A, selected on the basis of their effects in similar aversively motivated tests of latent inhibition, were without intrinsic effect in the present procedure. The dose-related dissociation between trace and contextual conditioning effects under PD 149163 is considered as cognitive enhancement.

Key Words: aversive conditioning • trace conditioning • neurotensin • PD 149163 • SR 1 42948A • rat

This version was published on May 1, 2008

Journal of Psychopharmacology, Vol. 22, No. 3, 290-299 (2008)
DOI: 10.1177/0269881106081528


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