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Journal of Psychopharmacology
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Reduced thalamic grey matter volume in opioid dependence is influenced by degree of alcohol use: a voxel-based morphometry study

Alastair G. Reid

Psychopharmacology Unit, University of Bristol, Bristol BS1 3NY, UK, MRC PET Psychiatry Group, Hammersmith Hospital, London W12 0NN, UK, alastair.reid @bristol.ac.uk

Mark R. C. Daglish

Psychopharmacology Unit, University of Bristol, Bristol BS1 3NY, UK, MRC PET Psychiatry Group, Hammersmith Hospital, London W12 0NN, UK

Matthew J. Kempton

Centre for Neuroimaging Sciences/ Neurobiology of Psychosis, Institute of Psychiatry, London SE5 8AF, UK

Tim M. Williams

Psychopharmacology Unit, University of Bristol, Bristol BS1 3NY, UK

Ben Watson

Psychopharmacology Unit, University of Bristol, Bristol BS1 3NY, UK, MRC PET Psychiatry Group, Hammersmith Hospital, London W12 0NN, UK

David J. Nutt

Psychopharmacology Unit, University of Bristol, Bristol BS1 3NY, UK

Anne R. Lingford-Hughes

0 MRC PET Psychiatry Group, Hammersmith Hospital, London, W12 0NN, U, Psychopharmacology Unit, University of Bristol, Bristol, BS1 3NY, UK

The aim of this study was to make a comparison of brain structure between a group of opioid-dependent subjects and healthy controls. We report the results of an `optimized' voxel-based morphometry study on a sample of nine opioid-dependent subjects with no comorbid substance misuse disorders versus 21 healthy controls. We found a significant reduction in grey matter volume of the thalamus after controlling for age and total grey matter volume. Regression analysis of substance use variables in the opioid-dependent sample shows that only level of alcohol use negatively predicts grey matter volume for this region of difference. We suggest that level of nondependent alcohol use could influence reduced thalamic grey matter volume in opioid-dependent subjects.

Key Words: opioid-dependence • opioid • addict • neuroimaging • MRI • VBM • voxel-based morphometry • alcohol • thalamus

Journal of Psychopharmacology, Vol. 22, No. 1, 7-10 (2008)
DOI: 10.1177/0269881107080795
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