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Journal of Psychopharmacology
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0269881106073596v1
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*CITALOPRAM HYDROBROMIDE
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*Depression
*Diets
*High Blood Pressure
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Citalopram-induced SIADH in a hypertensive patient on salt restricted diet

Yasin Bez

Marmara University School of Medicine, Department of Psychiatry, Istanbul, Turkey, yasinbez{at}gmail.com

Serdal Aktolga

Marmara University School of Medicine, Department of Internal Medicine, Istanbul, Turkey

Merih Balci

Marmara University School of Medicine, Department of Internal Medicine, Istanbul, Turkey

Serdar Nurmedov

Marmara University School of Medicine, Department of Psychiatry, Istanbul, Turkey

Volkan Topçuoglu

Marmara University School of Medicine, Department of Psychiatry, Istanbul, Turkey

Hyponatraemia is a very rare but potentially fatal complication of SSRIs and citalopram therapy, especially during the first weeks of treatment and for those who concomitantly use medications known to cause hyponatraemia. We present a 54-year-old hypertensive female patient who was admitted to the hospital with drowsiness, paresthesia, fatigue, nausea, vomiting and visual hallucinations and who was diagnosed to have syndrome of inappropriate secretion of antidiuretic hormone (SIADH) due to citalopram. All her presenting symptoms disappeared after discontinuation of citalopram therapy, fluid restriction and a careful hypertonic saline infusion. This case suggests that SIADH may develop among hypertensive patients, especially when they use diuretics or follow a salt restricted diet.

Key Words: Citalopram • SIADH • hyponatraemia • diet

This version was published on August 1, 2007

Journal of Psychopharmacology, Vol. 21, No. 6, 665-667 (2007)
DOI: 10.1177/0269881106073596
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