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A naturalistic, 9-month follow-up, comparing olanzapine and conventional antipsychotics on sexual function and hormonal profile for males with schizophrenia

Department of Psychiatry, Federal University of São Paulo, SP, Brazil

Mauricio Silva de Lima

Department of Psychiatry, Federal University of Pelotas and Catholic University of Pelotas, RS, Brazil; Clinical Research, Eli Lilly Brazil

Marité Faria

Clinical Research, Eli Lilly Brazil

Salomão Rodrigues Filho

Pax Clínica Psiquiátrica, Goiania, GO, Brazil

Irismar Reis De Oliveira

Department of Psychiatry and Neurology, Federal University of Bahia, BA, Brazil

Jair de Jesus Mari

Department of Psychiatry, Federal University of São Paulo, SP, Brazil

Second generation antipsychotics have less influence on prolactin levels than conventional antipsychotics (CA), which are commonly associated with sexual dysfunction and hyperprolactinaemia. However, only a few studies have been conducted assessing these newer antipsychotics and sexual function/dysfunction. The aim of this study is to evaluate the sexual function and hormonal profile of male schizophrenic patients taking olanzapine or CA. Sixty-three inpatients with acute episodes of schizophrenia were randomly assigned to take either olanzapine, or go on conventional antipsychotic treatment. The Dickson-Glazer sexual functioning questionnaire was used to assess sexual functioning where serum prolactin, luteinizing hormone, follicle-stimulating hormone, total testosterone, free testosterone, and sex hormone-binding globulin concentrations were measured. All measurements were taken on discharge from the inpatient unit (baseline), and again at 3 and 9 months after discharge. Prolactin levels in the olanzapine group decreased more rapidly and were significantly lower than in the CA group after 3 months (12.1±6.3µg/l, p=0.01; 18.1±11.2µg/l, p=0.564, respectively). After nine months, there was a tendency toward normal levels in both groups, and the frequency of sexual complaints did not differ between the groups. This study showed no difference between olanzapine and conventional antipsychotics regarding sexual complaints in the treatment of schizophrenia, but did show a difference in the hormone level normalization rate.

Key Words: schizophrenia • sexual dysfunction • hormones • prolactin • olanzapine • antipsychotics

Journal of Psychopharmacology, Vol. 21, No. 2, 165-170 (2007)
DOI: 10.1177/0269881107066333


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