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Journal of Psychopharmacology
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0269881106063134v1
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Methylphenidate for {alpha}-interferon induced depression

Alvaro Camacho

Bernardo Ng

Sun Valley Behavioral Medical Center & Imperial County Behavioral Health Department of Psychiatry, University of California, San Diego, CA, USA

Interferon-Alpha (IFN) has been effective in the treatment of chronic viral infections and cancer albeit the added risk of severe depression. The literature has reported effectiveness in the use of antidepressants for interferon-induced depression. We report a case of severe protracted depression induced by IFN in a patient diagnosed with melanoma who responded rapidly to a course of methylphenidate using the Hamilton Depressive Rating Scale. Methylphenidate appeared to be effective in the treatment of neurovegetative symptoms of major depression induced by IFN. This report provides further clinical evidence that the neurovegetative symptoms of depression might respond better to a norepinephrine uptake inhibitor or psycho-stimulants.

Key Words: methylphenidate • depression • interferon

This version was published on September 1, 2006

Journal of Psychopharmacology, Vol. 20, No. 5, 687-689 (2006)
DOI: 10.1177/0269881106063134
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