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Journal of Psychopharmacology
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Reliability of salivary cortisol assessments in cocaine dependent individuals

H. C. Fox

E. H. Wilker

Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA

M. J. Kreek

Rockefeller University, New York, NY, USA

R. Sinha

Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA

The aim of this study was to assess the reliability of salivary cortisol as a measure of hypothalmic–pituitary–adrenal (HPA) axis function in cocaine dependent individuals. Saliva and total plasma samples were collected from 49 abusers on 3 testing days in the morning, across eight time points per day. Significant associations between saliva and plasma cortisol were observed across all time points collapsed across 3 days in both men and women. These moderately significant correlations suggest that salivary measurements represent a stable, non-invasive and broad indicator of HPA axis functioning in cocaine dependent individuals.

Key Words: salivary cortisol • plasma cortisol • cocaine • HPA axis

This version was published on September 1, 2006

Journal of Psychopharmacology, Vol. 20, No. 5, 650-655 (2006)
DOI: 10.1177/0269881106063474
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