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Journal of Psychopharmacology
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0269881105057515v1
20/3/347    most recent
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Lithium: a review of its metabolic adverse effects

Callum Livingstone

Clinical Biochemistry Department, Royal Surrey County Hospital, Guildford, Surrey, UK

Hagen Rampes

Barnet, En.eld and Haringey Mental Health NHS Trust, Northwest Community Mental Health Team, 7th Floor Premier House, 112 Station Road, Edgware, Middlesex, UK

Treatment with lithium has long been recognized to be associated with metabolic adverse effects notably hypothyroidism, hyperparathyroidism, weight gain and nephrogenic diabetes insipidus. It is important that clinicians prescribing lithium are aware of these adverse effects and have a strategy for their detection and management. We review aspects of these actions of lithium including their prevalence, risk factors, biochemical changes involved and management, and discuss some advances that have been made in their understanding in recent years.

Key Words: lithium • adverse effects • hypothyroidism • obesity • hyperparathyroidism • diabetes insipidus

This version was published on May 1, 2006

Journal of Psychopharmacology, Vol. 20, No. 3, 347-355 (2006)
DOI: 10.1177/0269881105057515
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