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A comparison of multiple 5-HT receptors in two tasks measuring impulsivity

Department of Experimental Psychology, University of Cambridge, Cambridge, CB2 3EB, UK, jt286{at}cam.ac.uk

Lawrence S. Wilkinson

Laboratory of Cognitive and Behavioural Neuroscience, Babraham Institute, Cambridge, CB2 4AT, UK

Trevor W. Robbins

Department of Experimental Psychology, University of Cambridge, Cambridge, CB2 3EB, UK

Impulsivity has often been assumed to be a unitary construct. However dissociable forms of impulsive behaviour may exist, each with distinct neurochemical underpinnings. To test this hypothesis, behavioural effects of three partially selective serotonergic (5-HT) ligands, ketanserin (5-HT2_{A, C} receptor antagonist), SER-082 (5-HT2_{C, B} receptor antagonist) and SB-270146-A (5-HT6 receptor antagonist) were compared in two tests of impulsivity. The five-choice serial reaction time task (5-csrtt) and a delayed reward task were chosen as they measure theoretically different types of impulsivity, behavioural inhibition versus choice preference for a delayed reward. Dissociation was seen between the effects of ketanserin, which decreased impulsivity in the 5-csrtt, but had no effect on the delayed reward task, and SER-082, which had no effect on the 5-csrtt, but decreased impulsive responding in the delayed reward task. SB-270146-A had no effect in either paradigm. The results suggest that the 5-csrtt and the delayed reward task do in fact measure different types of impulsive behaviour, which are at least partially neurochemically distinct.

Key Words: impulsivity • attention • delayed reward • 5-csrtt • 5-HT2a • 5-HT2c • 5-HT6 • behavioural inhibition • ADHD

This version was published on January 1, 2006

Journal of Psychopharmacology, Vol. 20, No. 1, 47-58 (2006)
DOI: 10.1177/0269881105056639


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