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Journal of Psychopharmacology
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Increased libido associated with quetiapine

Anuradha Menon

St. George’s Hospital, Morpeth, Northumberland, UK

R. Hamish McAllister Williams

School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, Newcastle upon Tyne, UK

Stuart Watson

School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, Newcastle upon Tyne, UK. Mental Health Unit, Leazes Wing, RVI, Newcastle, UK, stuart.watson{at}ncl.ac.uk

We report sexual symptoms in a 44 year old man with schizophrenia who was receiving treatment with the atypical antipsychotic quetiapine. The symptoms consisted of an increased drive to masturbate and spontaneous ejaculations at night time. We discuss the potential neuro-chemical mechanisms for this and argue that quetiapine’s unique pharmacological profile may have contributed to the development of his symptoms.

Key Words: quetiapine • libido • neurotransmitters • serotonin • adrenoceptor • prolactin • dopamine

Journal of Psychopharmacology, Vol. 20, No. 1, 125-127 (2006)
DOI: 10.1177/0269881106059732
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