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Objective and subjective effects of remoxipride, alone and in combination with ethanol or diazepam, on performance in healthy subjects

Department of Pharmacology and Toxicology, University of Helsinki, Helsinki, Finland

M.E. Mattila

Department of Pharmacology and Toxicology, University of Helsinki, Helsinki, Finland

K. Konno

National Medicines Laboratory, Helsinki, Finland

U. Saarialho-Kere

Department of Pharmacology and Toxicology, University of Helsinki, Helsinki, Finland

Effects on human performance of remoxipride (RX), an antipsychotic drug of substituted benzamide structure, were studied in a randomized double-blind crossover trial where 12 young healthy volunteers took at 1 week intervals single oral doses of placebo or remoxipiride 100 mg both alone and in combination with 15 mg diazepam (DZ) or 0.8 g/kg ethanol (EtOH). Objective (digit symbols, tracking, choice reaction, flicker fusion, Maddox wing, body balance, memory) and subjective (visual analogue scales, questionnaire) tests were administered at baseline and 1.5, 3, 4.5 and 6 h post-treatment.

Journal of Psychopharmacology, Vol. 2, No. 3-4, 138-149 (1988)
DOI: 10.1177/026988118800200303


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