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Measures of anxiety and stress in the rat following chronic treatment with yohimbine

MRC Neuropharmacology Research Group, Department of Pharmacology, The School of Pharmacy, University of London, 29-39 Brunswick Square, London WC1N 1AX

Helen A. Baldwin

MRC Neuropharmacology Research Group, Department of Pharmacology, The School of Pharmacy, University of London, 29-39 Brunswick Square, London WC1N 1AX

Sandra E. File

MRC Neuropharmacology Research Group, Department of Pharmacology, The School of Pharmacy, University of London, 29-39 Brunswick Square, London WC1N 1AX

Yohimbine (2.5 and 5 mg/kg) was investigated in two animal tests of anxiety and on baseline corticosterone plasma concentrations, following both acute and chronic administration. Acute treatment with yohimbine produced the following effects: a reduction in the percentage of total arm entries made onto the open arms and in the percentage of time spent on the open arms of an elevated plus-maze (indicating anxiogenic properties), an increase in baseline plasma corticosterone concentrations, and a reduction in locomotor activity (recorded in the social interaction test). No significant effects were observed on anxiety levels as measured by the social interaction test. Following chronic treatment, we saw no evidence for sensitization to the effects of yohimbine.

Journal of Psychopharmacology, Vol. 2, No. 1, 33-38 (1988)
DOI: 10.1177/026988118800200106


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