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Corticotropin-releasing factor immunoreactivity in post-mortem brain from depressed suicides

Bruce G. Charlton

MRC Neuroendocrinology Unit, Newcastle General Hospital, Newcastle-upon-Tyne NE4 6BE, U.K.

Sharon C. Cheetham

Department of Pharmacology and Clinical Pharmacology, St George's Hospital Medical School, London SW17 ORE, U.K.

Roger W. Horton

Department of Pharmacology and Clinical Pharmacology, St George's Hospital Medical School, London SW17 ORE, U.K.

Cornelius L. E. Katona

Department of Psychiatry, Middlesex Hospital Medical School, London W1A 8AA, U.K.

M. Rufus Crompton

Department of Forensic Medicine, St George's Hospital Medical School, London SW17 ORE, U.K.

I. Nicol Ferrier

MRC Neuroendocrinology Unit, Newcastle General Hospital, Newcastle-upon-Tyne NE4 6BE, U.K.

Corticotropin-releasing factor immunoreactivity (CRF-I) was measured in cortical brain tissue obtained at post-mortem from 12 suicide victims with clear evidence of depressive illness and 12 age-matched and sex-matched control subjects dying by natural causes. There were no significant differences in mean CRF-I concentrations in frontal, temporal, motor and parietal cortex between the total suicide group, or the eight drug-free suicides and their matched controls. These findings suggest that cortical CRF-I concentrations are unaltered in depressive illness and are discussed in relation to recent reports of elevated CRF-I con centrations in the cerebrospinal fluid of depressed patients.

Journal of Psychopharmacology, Vol. 2, No. 1, 13-18 (1988)
DOI: 10.1177/026988118800200103
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