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Neonatal symptoms following maternal paroxetine treatment: Serotonin toxicity or paroxetine discontinuation syndrome?

Bolton, Salford and Trafford Mental Health NHS Trust, Prestwich, Manchester, M25 3BL, UK, peterhaddad{at}doctors.org.uk

B. R. Pal

Department of Neonatal Medicine and Women’s Health, Hope Hospital, Salford, Manchester, M6 8HD, UK

P. Clarke

Department of Neonatal Medicine and Women’s Health, Hope Hospital, Salford, Manchester, M6 8HD, UK

A. Wieck

Northwest Perinatal Psychiatry Service, Wythenshawe Hospital, Manchester Mental Health and Social Care Trust, Wythenshawe, Manchester, M23 9LT, UK

S. Sridhiran

Bolton, Salford and Trafford Mental Health NHS Trust, Prestwich, Manchester, M25 3BL, UK

We report a case of neonatal symptoms of irritability, increased tonus and convulsions after in-utero exposure to paroxetine 30mg/day. The infant’s symptoms commenced on the first day after birth and persisted for 10 days. Paroxetine levels were undetectable on day 6. Extensive investigations excluded infective and metabolic causes. Serotonin toxicity due to paroxetine seems the most likely mechanism, though an important differential diagnosis is a paroxetine discontinuation (withdrawal) syndrome. Differentiating between these two syndromes in the neonate presents a dilemma for clinicians. Irrespective of the mechanism, we recommend that all neonates exposed to antidepressants, particularly serotonin reuptake inhibitors (SSRIs), during the last trimester should be followed-up closely for adverse symptoms commencing in the first 10 days after birth. The possibility of such symptoms needs to be discussed with women who are considering starting or continuing antidepressant treatment in pregnancy. All neonatal adverse drug events should be reported to a pharmacovigilance centre. Further research is warranted.

Key Words: antidepressants • selective serotonin reuptake inhibitors • withdrawal syndrome • serotonin syndrome • neonate • pregnancy

Journal of Psychopharmacology, Vol. 19, No. 5, 554-557 (2005)
DOI: 10.1177/0269881105056554


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