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Journal of Psychopharmacology
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Successfully switching acetylcholinesterase inhibitor therapy in probable Lewy body dementia

Fahad Khalifa Alwahhabi

College of Medicine, King Saud University, King Khalid University Hospital, Riyadh, Saudi Arabia, fahad_alwahhabi{at}yahoo.com

Lewy body disease is a common cause of dementia. Pharmacological therapies for the symptomatic treatment of this disorder are few and largely consist of acetylcholinesterase inhibitors. No guidelines exist regarding poor response or intolerability with such medications. This report discusses a case of an elderly woman with a diagnosis of probable Lewy body dementia who had significant improvement with donepezil but discontinuted it due to side effects. She was switched to rivastigmine which she tolerated and which had a similar clinical response. The process of switching is discussed in light of the lack of specific guidelines.

Key Words: acetylcholinesterase inhibitors • Lewy body demential • switching

Journal of Psychopharmacology, Vol. 19, No. 2, 214-216 (2005)
DOI: 10.1177/0269881105049045
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