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Journal of Psychopharmacology
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Sex differences in cortisol response to reboxetine

Wai S. Tse

Section of Clinical Psychopharmacology, Institute of Psychiatry, King’s College London, London, UK, sswstse{at}cityu.edu.hk

Alyson J. Bond

National Addiction Centre, Department of Psychological Medicine, Institute of Psychiatry, King’s College London, London, UK

This study examined the cortisol response to reboxetine in a sample of healthy men and women. Forty healthy volunteers were randomly allocated to one of two treatment groups: placebo or 4 mg reboxetine under double-blind conditions. Saliva cortisol was measured pre, 1 and 1.5 h post-treatment. Mood and side-effects were also measured. A single oral dose of 4 mg reboxetine did not affect positive or negative mood but did produce some side-effects. It was also sufficient to increase cortisol release 1.5 h post-treatment compared to placebo. In addition, reboxetine lead to a significantly increased cortisol release in male compared to female volunteers. The results suggest that healthy male volunteers are more responsive to challenge with a noradrenergic compound than females.

Key Words: cortisol • depression • noradrenaline • sex differences

Journal of Psychopharmacology, Vol. 19, No. 1, 46-50 (2005)
DOI: 10.1177/0269881105048896
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This article has been cited by other articles:


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 J PsychopharmacolHome page
S. R. Chamberlain, U. Muller, S. Cleary, T. W. Robbins, and B. J. Sahakian
Atomoxetine increases salivary cortisol in healthy volunteers
J Psychopharmacol, July 1, 2007; 21(5): 545 - 549.
[Abstract] [PDF]


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