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Topographical effects of D1-like dopamine receptor agonists on orofacial movements in mice and their differential regulation via oppositional versus synergistic D1-like: D2-like interactions: cautionary observations on SK&F 82958 as an anomalous agent

Department of Pharmacology, Nihon University School of Dentistry, Tokyo, Japan

Hiroshi Yamamoto

Department of Oral and Maxillofacial Surgery, Nihon University School of Dentistry, Tokyo, Japan

Mai Inoue

Department of Pharmacology, Tokyo University of Science, Tokyo, Japan

Katsunori Tomiyama

Department of Pharmacology and Dental Research Centre, Nihon University School of Dentistry, Tokyo, Japan, tomiyama{at}pharm.dent.nihon-u.ac.jp

Noriaki Koshikawa

Department of Pharmacology and Dental Research Centre, Nihon University School of Dentistry, Tokyo, Japan

John L. Waddington

Department of Clinical Pharmacology and Institute of Biopharmaceutical Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland

Using a novel procedure, the regulation of individual topographies of orofacial movement in the mouse by oppositional versus cooperative/synergistic D1-like: D2-like dopamine receptor interactions was studied. The D1-like agonists SK&F 38393 and SK&F 83959 each induced vertical, but not horizontal, jaw movements, together with tongue protrusions and incisor chattering; however, SK&F 82958 induced a different profile which, consistent with other neurochemical and neurophysiological studies, suggests that this agent shows anomalous properties relative to other D1-like agonists. When given alone, the D2-like agonist quinpirole reduced horizontal jaw movements and incisor chattering. On coadministration, both SK&F 38393- and SK&F 83959-induced vertical jaw movements and tongue protrusions were inhibited by quinpirole, while SK&F 82958 again showed an anomalous profile. These findings indicate that, in the mouse, vertical jaw movements and tongue protrusions are regulated by oppositional D1-like: D2-like interactions, and appear to involve a D1-like receptor that is not coupled to adenylyl cyclase, whereas horizontal jaw movements are inhibited by D2-like receptors. Additionally, results obtained using SK&F 82958 as a probe for D1-like mechanisms should be treated with considerable caution until they are confirmed using other D1-like agonists.

Key Words: dopamine receptor subtypes • D1-like agonists • D1-like receptors • D1-like • D2-like interactions • D2-like receptors • non-cyclase-coupled D1-like receptors • orofacial movements • topographical assessment

Journal of Psychopharmacology, Vol. 18, No. 4, 484-495 (2004)
DOI: 10.1177/0269881104047275


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