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Journal of Psychopharmacology
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Diabetic Keto-Acidotic (DKA) Coma following Olanzapine Initiation in a Previously Euglycaemic Woman and Successful Continued Therapy with Olanzapine

O. D. Howes

The Institute of Psychiatry, De Crespigny Park, London, UKo.howes{at}iop.kcl.ac.uk

L. Rifkin

The Maudsley Hospital, Denmark Hill, London, UK

We report the case of a euglycaemic woman whose glucose controlrapidly decompensated following olanzapine initiation leading todiabetic coma. Hyperglycaemia has been associated with chronicpsychotic disorders and antipsychotics for many years. However, it is unusual to see such rapid and life-threatening changes associated with treatment. The case highlights that changes in antipsychotic treatment may be associated with large changes in glucose tolerance, and that it is possible to continue antipsychotic treatment with appropriate diabetic care.

Key Words: antipsychotic • diabetes mellitus • DKA • olanzapine • psychosis • side-effects

Journal of Psychopharmacology, Vol. 18, No. 3, 435-437 (2004)
DOI: 10.1177/026988110401800317
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Home page
 Journal of Pharmacy PracticeHome page
A. R. Fulbright and K. T. Breedlove
Complete Resolution of Olanzapine-Induced Diabetic Ketoacidosis
Journal of Pharmacy Practice, August 1, 2006; 19(4): 255 - 258.
[Abstract] [PDF]


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