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Journal of Psychopharmacology
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Rhabdomyolysis and Compartment Syndrome with Coadministration of Risperidone and Simvastatin

Michael A. Webber

Indiana University School of Medicine, Indianapolis, IN, USA

Waqar Mahmud

Jeffery D. Lightfoot

Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA

Anantha Shekhar

Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USAashekhar{at}iupui.edu

We report a case of rhabdomyolysis and acute compartment syndrome of the lower extremity in a schizophrenic patient taking risperid one following the addition of simvastatin to treat hyperlipidemia. We suspect that disrupted drug metabolism, resulting from interactions with cytochrome P450 enzymes, rapidly elevated drug plasma levels, which then led to muscle toxicity. Clinicians who pharmacologically treatmedical comorbidities in patients receiving atypical antipsychotics must be proactive in anticipating potential drug–drug interactions.

Key Words: compartment syndrome • hyperlipidemia • risperidone • rhabdomyolysis • schizophrenia • simvastatin

Journal of Psychopharmacology, Vol. 18, No. 3, 432-434 (2004)
DOI: 10.1177/026988110401800316
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