This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Web of Science (4) Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Ferini-Strambi, L. Articles by Bianchi, A. Search for Related Content PubMed PubMed Citation Articles by Ferini-Strambi, L. Articles by Bianchi, A. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Social Bookmarking                         What's this?

Effects of Reboxetine on Sleep and Nocturnal Cardiac Autonomic Activity in Patients with Dysthymia

Sleep Disorders Center, Università Vita-Salute, IRCCS H San Raffaele, Italyferinistrambi.luigi{at}hsr.it

Mauro Manconi

Vincenza Castronovo

Laura Riva

Sleep Disorders Center, Università Vita-Salute, IRCCS H San Raffaele, Italy

Anna Bianchi

Department of Biomedical Engineering, Politecnico, Milan, Italy

Antidepressants may have sleep and autonomic side-effects. The acute and long-term effect of reboxetine (2 mg b.i.d.) on sleep and cardiac autonomic activity was compared with that of placebo in a single-blind study. Twelve patients affected by dysthymia underwent four polysomnographic studies at baseline (placebo); at night 3 (reboxetine; acute effect); at night 9 (reboxetine; intermediate-term effect); and at night 122 (reboxetine; chronic effect). After the first administration, reboxetine increased time awake after sleep onset, number of awakenings, percentage of stages 1 and 2 non-rapid eye movement (REM), and reduced the amount of stages 3–4 non-REM, but all these effects disappeared by continuing treatment. However, reboxetine caused a persistent suppression of REM sleep, which was accompanied by an increase of REM sleep latency. The spectral analysis of heart ratevariability showed a trend towards an increase in sympathetic activity with both acute and intermediate reboxetine use. Long-term treatment with 4 mg reboxetine does not cause significant changes in cardiac autonomic function.

Key Words: cardiac autonomic activity • dysthymia • insomnia • polysomnography • reboxetine • sleep

Journal of Psychopharmacology, Vol. 18, No. 3, 417-422 (2004)
DOI: 10.1177/026988110401800313


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?