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Journal of Psychopharmacology, Vol. 18, No. 1, 133-135 (2004)
DOI: 10.1177/0269881104043284
© 2004 British Association for Psychopharmacology

Bupropion in the management of apathy

C. Corcoran

Department of Psychiatry, Beaumont Hospital, Dublin, Ireland. corcoranciaran{at}oz.ie

M. L. Wong

Department of Psychiatry, Beaumont Hospital, Dublin, Ireland.

V. O’Keane

Department of Perinatal Psychiatry, Institute of Psychiatry, King’s College London, De Crespigny Park, London, UK.

We report on three males with prominent apathy as part of the symptom complex of depression or organic brain disease. Significant clinical responses were observed following treatment with bupropion, an antidepressant with dopamine (DA) reuptake activity. We present clinical evidence in support of the hypothesis that remission in these patients occurred as a consequence of bupropion-induced increases in central DA neurotransmission.

Key Words: apathy • bupropion • dopamine


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