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Journal of Psychopharmacology, Vol. 17, No. 4, 455-458 (2003)
DOI: 10.1177/0269881103174011

Reduced Bone Mineral Density in Patients with Schizophrenia Receiving Prolactin Raising Anti-Psychotic Medication

Anna Maria Meaney

Waterford Regional Hospital, Waterford, Ireland, London, UKannamariameaney{at}hotmail.com

Veronica O’Keane

Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, UK

Patients with schizophrenia frequently develop drug-induced hyperprolactinaemia and consequent hypogonadism. Reduced bone mineral density as a consequence of hyperprolactinaemia-induced hypogonadism has been well documented in medical, but not psychiatric, disorders. Little attention has been given to the potential risk of developing osteoporosis secondary to anti-psychotic-induced hyperprolactinaemia. Three cases are presented that illustrate how this debilitating but silent disease may affect even those young individuals with schizophrenia.

Key Words: osteoporosis • prolactin • schizophrenia


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