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Journal of Psychopharmacology
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*Anxiety
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Anxiogenic-Like Effect of Corticotropin-Releasing Factor Receptor 2 Antisense Oligonucleotides Infused into Rat Brain

Koichi Isogawa

Jotaro Akiyoshi

akiyoshi{at}oita-med.ac.jp

Takashi Tsutsumi

Kensuke Kodama

Yukiko Horinouti

Haruo Nagayama

Department of Neuropsychiatry, Oita Medical University, Hasama-Machi, Oita, Japan

Corticotropin-releasing factor (CRF) is widely distributed in the brain and coordinates behavioural responses to stress. Its receptor subtypes, CRF-R1 and CRF-R2, are expressed in the brain. For this study, we tested the effect of a continuous infusion of CRF-R2 antisense oligonucleotides into the lateral ventricle on anxiety-related behaviours in rats. Our results indicate that CRF-R2 antisense oligonucleotides produced an anxiogenic-like effect in elevated plus maze, black and white box and conditioned fear stress in rats. No significant effect on general locomotor activity was seen. These results indicate that inhibition of CRF-R2 induces an increase in anxiety-related behaviours suggesting an anxiogenic-like effect.

Key Words: antisense • anxiety • black and white box • conditioned fear stress • corticotropin-releasing factor • elevated plus maze

Journal of Psychopharmacology, Vol. 17, No. 4, 409-413 (2003)
DOI: 10.1177/0269881103174004
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