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Olanzapine for Recurrent Aggression in a Patient with Temporal Lobe Epilepsy who had Temporal Lobectomy

Department of Neuropsychiatry and Medical Psychology, Faculty of Medicine University of São Paulo, Ribeirão Preto, São Paulo, Brazil, School of Psychiatry and Behavioural Sciences, Neuroscience and Psychiatry Unit, University of Manchester, Manchester, UK, jaime.hallak{at}man.ac.uk

Serdar M. Dursun

School of Psychiatry and Behavioural Sciences, Neuroscience and Psychiatry Unit, University of Manchester, Manchester UK

Ricardo Guarnieri

Department of Neuropsychiatry and Medical Psychology, Faculty of Medicine, University of São Paulo, Ribeirão Preto, São Paulo, Brazil

Edna Almeida

Department of Neuropsychiatry and Medical Psychology, Faculty of Medicine, University of São Paulo, Ribeirão Preto, São Paulo, Brazil

Karinne Rezeck

Department of Neuropsychiatry and Medical Psychology, Faculty of Medicine, University of São Paulo, Ribeirão Preto, São Paulo, Brazil

José A. S. Crippa

Department of Neuropsychiatry and Medical Psychology, Faculty of Medicine, University of São Paulo, Ribeirão Preto, São Paulo, Brazil, Department of Psychological Medicine, Institute de Psychiatry, University of London, London, UK

Américo C. Sakamoto

Department of Neuropsychiatry and Medical Psychology, Faculty of Medicine, University of São Paulo, Ribeirão Preto, São Paulo, Brazil

Antonio W. Zuardi

Department of Neuropsychiatry and Medical Psychology, Faculty of Medicine, University of São Paulo, Ribeirão Preto, São Paulo, Brazil

John F. W. Deakin

School of Psychiatry and Behavioural Sciences, Neuroscience and Psychiatry Unit, University of Manchester, Manchester, UK.

We report the case of a patient with epilepsy who had interictal severe affective aggression, and whose epilepsy significantly improved (but not aggression) after successful temporal lobectomy. Olanzapine significantly improved these aggressive episodes refractory to neurosurgery and previous pharmacological treatments including antipsychotics, anticonvulsants/mood stabilizers and benzodiazepines.

Key Words: aggression • epilepsy • olanzapine • temporal lobectomy

Journal of Psychopharmacology, Vol. 17, No. 3, 350-351 (2003)
DOI: 10.1177/02698811030173020


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