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Journal of Psychopharmacology
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Effects of Gabapentin on Anxiety Induced by Simulated Public Speaking

Joao Quevedo

Tatiana Barichello

Laboratorio de Neurotoxicologia, Universidade do Extremo Sul Catarinense, Criciuma, Brasil.

Ivan Izquierdo

Monica R. M. Vianna

Fernanda de-Paris

Centro de Memória, Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brasil.

Joao V. Busnello

Flavio Kapczinski

Marcia K. Sant'Anna

Grupo de Psicofarmacologia, Departamento de Psiquiatria, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brasil.

The effects of gabapentin, 400 mg and 800 mg, on anxiety induced by simulated public speaking (SPS) were investigated. Thirty-two normal male volunteers (aged 17-30 years) had their anxiety and mood evaluated by self-scales [Visual Analogue Mood Scale (VAMS) and Profile of Mood State (POMS)] during the SPS procedure. Physiological measures (heart rate and blood pressure) were taken. Treatment with gabapentin at 800 mg attenuated the anxiety of subjects that had a decrease on the VAMS item calm-excite. In addition, volunteers that received gabapentin at 400 mg and 800 mg showed a decrease in the hostility score in POMS. Our results suggest, in agreement with other studies, an anxiolytic potential to gabapentin.

Key Words: anxiety • gabapentin • simulated public speaking

Journal of Psychopharmacology, Vol. 17, No. 2, 184-188 (2003)
DOI: 10.1177/0269881103017002006
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