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Emerging skin-picking behaviour after serotonin reuptake inhibitor-treatment in patients with obsessive–compulsive disorder: possible mechanisms and implications for clinical care

Department of Psychiatry, University Medical Centre, Utrecht, The Netherlands; UMC B.01.206 PO Box 85500 3508 GA Utrecht The Netherlands, d.a.j.p.denys{at}azu.nl

Harold J. G. M. van Megen

Herman G. M. Westenberg

Department of Psychiatry, University Medical Centre, Utrecht, The Netherlands

Pathological skin-picking is a self-injurious, impulsive behaviour with repetitive, and ritualistic characteristics. A number of studies show that selective serotonin reuptake inhibitors (SSRIs) may be efficacious in reducing skin-picking behaviour. Two case reports are presented demonstrating that SSRI-treatment may induce or aggravate pathological skin-picking behaviour. Possible mechanisms of SSRI-induced pathological skin-picking and implications for clinical care are discussed.

Key Words: impulse control disorders • obsessive compulsive disorder • pharmacotherapy • serotonin reuptake inhibitors • side effects • skin-picking

Journal of Psychopharmacology, Vol. 17, No. 1, 127-129 (2003)
DOI: 10.1177/0269881103017001718


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