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Cerebrospinal fluid monoamine metabolites in cocaine patients: no relationship to cue-induced craving

Psychiatry Service 116A, Department of Veterans Affairs, New Jersey Healthcare System, 385 Tremont Avenue, East Orange, NJ 07018, USA Alec.Roy{at}med.va.gov

Jeffrey Berman

Bienvenido Gonzalez

Monique Roy

Psychiatry Service 116A, Department of Veterans Affairs, New Jersey Healthcare System, East Orange, NJ, USA

We aimed to examine the relationship between central monoamine metabolites and craving cocaine in cocaine-dependent patients. Cerebrospinal fluid (CSF) monoamine metabolite concentrations were determined in 20 withdrawn cocaine-dependent patients. Patients also participated in a cue-elicited cocaine craving procedure. There were no significant relationships between cocaine craving scores and CSF concentrations of the dopamine metabolite, homovanillic acid, the serotonin metabolite, 5-hydroxyindoleacetic acid, or the norepinephrine metabolite, 3-methoxy-4-hydroxyphenylethylglycol. CSF monoamine metabolite concentrations were not related to cocaine craving in withdrawn cocaine-dependent patients.

Key Words: cocaine • craving • dopamine • norepinephrine • serotonin

Journal of Psychopharmacology, Vol. 16, No. 3, 227-229 (2002)
DOI: 10.1177/026988110201600306


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