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Cocaine-primed craving and its relationship to depressive symptomatology in individuals with cocaine dependence

Department of Psychiatry, Motivation and Emotion Neuroscience Center (MENC) Department of Radiology, Massachusetts General Hospital and Harvard Medical School Harvard University, Boston, MA, USA; elman.igor{at}mgh.harvard.edu

Katherine H. Karlsgodt

Department of Psychiatry, Motivation and Emotion Neuroscience Center (MENC) Department of Radiology, Massachusetts General Hospital and Harvard Medical School Harvard University, Boston, MA, USA

David R. Gastfriend

Department of Psychiatry, Harvard University, Boston, MA, USA

Christopher F. Chabris

Department of Psychology, Harvard University, Boston, MA, USA

Hans C. Breiter

Department of Psychiatry, Motivation and Emotion Neuroscience Center (MENC) Department of Radiology, Massachusetts General Hospital and Harvard Medical School Harvard University, Boston, MA, USA

Several lines of evidence suggest a link between cocaine-primed craving and depressive symptomatology. The purpose of this study was to directly relate these two clinical phenomena. Thirty-three cocainedependent subjects were rated on the Hamilton Rating Scale for Depression (HRSD) at baseline and then administered an i.v. bolus of cocaine (0.2 mg/kg). Multiple regression analysis revealed that only the HRSD score was an independent predictor of cocaine-primed craving (F= 4.09; d.f. = 10,22; r=0.81, p< 0.003) when baseline spontaneous craving during early withdrawal, age, gender, frequency of use, time since last use, monetary expenditure on cocaine and the Addiction Severity Index Drug Composite Scores were considered. These data support the hypothesis that depressive symptomatology affects cocaine-primed craving and that this relationship is relatively specific to symptoms defined by the HRSD and is not seen with a number of other clinical and demographic variables.

Key Words: Addiction Severity Index • cocaine infusion • euphoria • Hamilton Rating Scale for Depression • high • multidimensional craving questionnaire • non-treatment seekers

Journal of Psychopharmacology, Vol. 16, No. 2, 163-167 (2002)
DOI: 10.1177/026988110201600207


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