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Journal of Psychopharmacology
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Lethal catatonia responding to high-dose olanzapine therapy

E. M. Cassidy

Department of Psychiatry, Royal College of Surgeons in Ireland and Beaumont Hospital, Dublin, Republic of Ireland; Room 32, Department of Neuropsychiatry Maudsley Hospital Denmark Hill London SE5 8AZ UK eucass{at}hotmail.com

M. O'Brien

Department of Psychiatry, Royal College of Surgeons in Ireland and Beaumont Hospital, Dublin, Republic of Ireland

M. F. Osman

J. Finucane

Department of Medicine, Royal College of Surgeons in Ireland and Beaumont Hospital, Dublin, Republic of Ireland

V. O'Keane

Department of Psychiatry, Royal College of Surgeons in Ireland and Beaumont Hospital, Dublin, Republic of Ireland

We present the case of a 31-year-old woman with recent refractory bipolar disorder who developed a malignant syndrome preceded by catatonic motor features. This resistant case of lethal catatonia responded selectively to high-dose olanzapine treatment. The case illustrates the need to consider lethal catatonia in apparent cases of neuroleptic malignant syndrome that do not respond to conventional treatment with dantrolene and bromocriptine.

Key Words: catatonia • lethal • neuroleptic malignant syndrome • olanzapine

Journal of Psychopharmacology, Vol. 15, No. 4, 302-304 (2001)
DOI: 10.1177/026988110101500412
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