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Antipsychotic drugs result in the formation of immature neutrophil leucocytes in schizophrenic patients

University College of Wales, Bangor, Faculty of Health Studies, Archimedes Centre, Wrexham Technology Park, Wrexham

M. Badawoud

M. A. Williams

Department of Biomedical Science, Sheffield University, Sheffield

R. W. Horobin

Division of Neuroscience and Biomedical Systems West Medical Building Institute of Biomedical and Life Sciences The University of Glasgow Glasgow G12 8QQ UK RichardWHorobin{at}aol.com

J. K. Duguid

Department of Haematology, Wrexham Maelor Hospital, Wrexham, UK

Subclinical abnormality of neutrophil populations of patients suffering from schizophrenia and medicated with antipsychotic drugs was evaluated using cellular immaturity as a criterion. Neutrophil maturity of patients and controls was compared by determining mean nuclear lobularity in peripheral blood smears. White blood cell and neutrophil counts were made. Subjects were patients medicated with chlorpromazine (n = 17) or clozapine (n = 48). Controls (n = 58) were healthy, non-medicated clinical and academic staff. Determination of mean lobe number involved assessment of 300 neutrophils per individual. For subject and control groups, means and medians of mean lobe numbers and mean white cell and neutrophil counts were determined. Means for each group were compared using the Mann–Whitney U-test; variances using Fratios. Means of lobe numbers of both patient populations were significantly different (p < 0.0001) compared to controls. Two-thirds of patients had mean lobe numbers outside the control range. Dose–response (mean lobe number) plots were significant for patients medicated with both chlorpromazine and clozapine. White cell and neutrophil counts in patients and controls did not differ significantly. For six patients, mean lobe numbers were obtained before and after medication commenced and all showed lowering of mean lobe number. The mean lobe number of the one patient who subsequently suffered from agranulocytosis was at the low end of the patient range. Thus, patients medicated with antipsychotic drugs typically have immature neutrophils, but normal white cell and neutrophil numbers. This effect is probably drug-induced. Mean lobe number may predict patients at risk from agranulocytosis.

Key Words: agranulocytosis • antischizophrenic medication • chlorpromazine • clozapine • neutrophilis • nuclear lobe count • schizophrenia

Journal of Psychopharmacology, Vol. 15, No. 3, 191-194 (2001)
DOI: 10.1177/026988110101500306


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				J. M. Delieu, R. W. Horobin, and J. K. Duguid Formation of immature neutrophil leucocytes in schizophrenic patients treated with various antipsychotic drugs: comparisons and predictions J Psychopharmacol, November 1, 2006; 20(6): 824 - 828. [Abstract] [PDF]