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Journal of Psychopharmacology
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Neuroleptic malignant-like syndrome after abrupt withdrawal of baclofen

M. R. Turner

Academic Neurosciences Centre, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, UK; m.turner{at}iop.kcl.ac.uk

N. Gainsborough

Royal Sussex County Hospital, Brighton, East Sussex, UK

We present the case of a 36-year-old man who presented with a clinically neuroleptic malignant-like syndrome involving disorientation, signs of autonomic dysfunction, rigidity and raised total creatine kinase level, but in the absence of any neuroleptic medication. He had, however, abruptly stopped taking his longterm baclofen in the days prior to presentation. He improved markedly after the reintroduction of baclofen, and we postulate that his clinical syndrome resulted from the sudden withdrawal of this drug. We concur with the concept that neuroleptic malignant syndrome represents a spectrum of disorders, and add it to the list of possible sequelae after abrupt withdrawal of baclofen.

Key Words: baclofen • creatine kinase • neuroleptic malignant syndrome

Journal of Psychopharmacology, Vol. 15, No. 1, 61-63 (2001)
DOI: 10.1177/026988110101500111
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This article has been cited by other articles:


Home page
 PsychosomaticsHome page
R. J. Leo and D. Baer
Delirium Associated With Baclofen Withdrawal: A Review of Common Presentations and Management Strategies
Psychosomatics, December 1, 2005; 46(6): 503 - 507.
[Abstract] [Full Text] [PDF]


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